March 2017 Member Publications

Selected Publications

Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion. Stearns-Reider KM, D'Amore A, Beezhold K, Rothrauff B, Cavalli L, Wagner WR, Vorp DA, Tsamis A, Shinde S, Zhang C, Barchowsky A, Rando TA, Tuan RS, Ambrosio F. Aging Cell. 2017 Mar 30.

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens. Khodadoust MS, Olsson N, Wagar LE, Haabeth OA, Chen B, Swaminathan K, Rawson K, Liu CL, Steiner D, Lund P, Rao S, Zhang L, Marceau C, Stehr H, Newman AM, Czerwinski DK, Carlton VE, Moorhead M, Faham M, Kohrt HE, Carette J, Green MR, Davis MM, Levy R, Elias JE, Alizadeh AA. Nature. 2017 Mar 30;543(7647):723-727.

Are Novel Anticoagulants Worth Their Cost? Hlatky MA. JAMA Cardiol. 2017 Mar 29.

Potent P2Y₁₂ Inhibitors in Men Versus Women: A Collaborative Meta-Analysis of Randomized Trials. Lau ES, Braunwald E, Murphy SA, Wiviott SD, Bonaca MP, Husted S, James SK, Wallentin L, Clemmensen P, Roe MT, Ohman EM, Harrington RA, Mega JL, Bhatt DL, Sabatine MS, O'Donoghue ML. J Am Coll Cardiol. 2017 Mar 28;69(12):1549-1559.

Extended hybrid-space SENSE for EPI: Off-resonance and eddy current corrected joint interleaved blip-up/down reconstruction. Zahneisen B, Aksoy M, Maclaren J, Wuerslin C, Bammer R. Neuroimage. 2017 Mar 28;153:97-108.

Collateral Damage: Sufficient Coronary Collaterals Provide Important, Yet Limited, Protection in Chronic Total Occlusions. Parikh RV, Fearon WF. JACC Cardiovasc Interv. 2017 Mar 27;10(6):594-596.

Peripheral Endothelial Function After Arterial Switch Operation for D-looped Transposition of the Great Arteries. Sun HY, Stauffer KJ, Nourse SE, Vu C, Selamet Tierney ES. Pediatr Cardiol. 2017 Mar 27.

Predictive value of device-derived activity level for short-term outcomes in MADIT-CRT. Jamé S, Kutyifa V, Polonsky B, McNitt S, Al-Ahmad A, Moss AJ, Zareba W, Wang PJ. Heart Rhythm. 2017 Mar 25.

Development and validation of a major adverse transplant event (MATE) score to predict late graft loss in pediatric heart transplantation. Almond CS, Hoen H, Rossano JW, Castleberry C, Auerbach SR, Yang L, Lal AK, Everitt MD, Fenton M, Hollander SA, Pahl E, Pruitt E, Rosenthal DN, McElhinney DB, Daly KP, Desai M; Pediatric Heart Transplant Study (PHTS) Group Registry. J Heart Lung Transplant. 2017 Mar 24.

Tolerogenic interactions between CD8₊ dendritic cells and NKT cells prevent rejection of bone marrow and organ grafts. Hongo D, Tang X, Zhang X, Engleman EG, Strober S. Blood. 2017 Mar 23;129(12):1718-1728.

Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons. Chuang W, Sharma A, Shukla P, Li G, Mall M, Rajarajan K, Abilez OJ, Hamaguchi R, Wu JC, Wernig M, Wu SM. Sci Rep. 2017 Mar 22;7:44840.

Change in Aortic Neck Diameter after Endovascular Aortic Aneurysm Repair. Kret MR, Tran K, Lee JT. Ann Vasc Surg. 2017 Mar 21.

Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. Wong WT, Matrone G, Tian X, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP. Elife. 2017 Mar 21;6.

Successful and Maladaptive T Cell Aging. Goronzy JJ, Weyand CM. Immunity. 2017 Mar 21;46(3):364-378.

A novel inflow cannulation strategy for pediatric mechanical circulatory support in small left ventricles. Ma M, Yarlagadda VV, Rosenthal DN, Maeda K. J Thorac Cardiovasc Surg. 2017 Mar 19.

Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery. Mehta RH, Leimberger JD, van Diepen S, Meza J, Wang A, Jankowich R, Harrison RW, Hay D, Fremes S, Duncan A, Soltesz EG, Luber J, Park S, Argenziano M, Murphy E, Marcel R, Kalavrouziotis D, Nagpal D, Bozinovski J, Toller W, Heringlake M, Goodman SG, Levy JH, Harrington RA, Anstrom KJ, Alexander JH; LEVO-CTS Investigators. N Engl J Med. 2017 Mar 19.

Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability. Hussain H, Du Y, Tikhonova E, Mortensen JS, Ribeiro O, Santillan C, Das M, Ehsan M, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. Chemistry. 2017 Mar 17.

Cardiac Regeneration: Lessons From Development. Galdos FX, Guo Y, Paige SL, VanDusen NJ, Wu SM, Pu WT. Circ Res. 2017 Mar 17;120(6):941-959.

Exclusion of Elderly People from Randomized Clinical Trials of Drugs for Ischemic Heart Disease. Bourgeois FT, Orenstein L, Ballakur S, Mandl KD, Ioannidis JP. J Am Geriatr Soc. 2017 Mar 17.

Resting-State Functional Connectivity Predicts Longitudinal Pain Symptom Change In Urologic Chronic Pelvic Pain Syndrome: A Mapp Network Study. Kutch JJ, Labus JS, Harris RE, Martucci KT, Farmer MA, Fenske S, Fling C, Ichesco E, Peltier S, Petre B, Guo W, Hou X, Stephens AJ, Mullins C, Clauw DJ, Mackey SC, Apkarian AV, Landis JR, Mayer EA; MAPP Research Network. Pain. 2017 Mar 17.

Effect of Atrial Fibrillation on Mortality, Stroke Risk, and Quality-of-Life Scores in Patients With Heart Failure (from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF]). Cherian TS, Shrader P, Fonarow GC, Allen LA, Piccini JP, Peterson ED, Thomas L, Kowey PR, Gersh BJ, Mahaffey KW. Am J Cardiol. 2017 Mar 16.

The use of intraosseous needles for injection of contrast media for computed tomographic angiography of the thoracic aorta. Winkler M, Talley C, Woodward C, Kingsbury A, Appiah F, Elbelasi H, Landwher K, Li X, Fleischmann D. J Cardiovasc Comput Tomogr. 2017 Mar 16.

Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants. Cunningham AD, Colavin A, Huang KC, Mochly-Rosen D. Cell Rep. 2017 Mar 14;18(11):2592-2599.

Coronary Endothelial Dysfunction and the Index of Microcirculatory Resistance as a Marker of Subsequent Development of Cardiac Allograft Vasculopathy. Lee JH, Okada K, Khush K, Kobayashi Y, Sinha S, Luikart H, Valantine H, Yeung AC, Honda Y, Fearon WF. Circulation. 2017 Mar 14;135(11):1093-1095.

Trade-off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome: lessons from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) randomized trial. Valgimigli M, Costa F, Lokhnygina Y, Clare RM, Wallentin L, Moliterno DJ, Armstrong PW, White HD, Held C, Aylward PE, Van de Werf F, Harrington RA, Mahaffey KW, Tricoci P. Eur Heart J. 2017 Mar 14;38(11):804-810.

The Academic Medical System: Reinvention to Survive the Revolution in Health Care. Konstam MA, Hill JA, Kovacs RJ, Harrington RA, Arrighi JA, Khera A; Academic Cardiology Section Leadership Council of the American College of Cardiology. J Am Coll Cardiol. 2017 Mar 14;69(10):1305-1312.

An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors. Ieyasu A, Ishida R, Kimura T, Morita M, Wilkinson AC, Sudo K, Nishimura T, Ohehara J, Tajima Y, Lai CY, Otsu M, Nakamura Y, Ema H, Nakauchi H, Yamazaki S. Stem Cell Reports. 2017 Mar 14;8(3):500-508.

Early non-persistence with dabigatran and rivaroxaban in patients with atrial fibrillation. Jackevicius CA, Tsadok MA, Essebag V, Atzema C, Eisenberg MJ, Tu JV, Lu L, Rahme E, Ho PM, Turakhia M, Humphries KH, Behlouli H, Zhou L, Pilote L. Heart. 2017 Mar 12.

Effects of Transendocardial CD34₊ Cell Transplantation on Diastolic Parameters in Patients with Nonischemic Dilated Cardiomyopathy. Bervar M, Kozelj M, Poglajen G, Sever M, Zemljic G, Frljak S, Cukjati M, Cernelc P, Haddad F, Vrtovec B. Stem Cells Transl Med. 2017 Mar 11.

Quantitative Analysis of Synthetic Cell Lineage Tracing Using Nuclease Barcoding. Schmidt ST, Zimmerman SM, Wang J, Kim SK, Quake SR. ACS Synth Biol. 2017 Mar 10.

Late breaking trials of 2016 in coronary artery disease: Commentary covering SCAI, ACC, TCT, EuroPCR, ESC, and AHA. Seto AH, Dehghani P, Shah B, Anwaruddin S, Safirstein J, Tremmel JA. Catheter Cardiovasc Interv. 2017 Mar 9.

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. Ho CC, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC. Cell. 2017 Mar 9;168(6):1041-1052.e18.

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx. Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK. Cell Metab. 2017 Mar 7;25(3):622-634.

Treatment Consistency Across Levels of Baseline Renal Function With Rivaroxaban or Warfarin: A ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) Analysis. Lindner SM, Fordyce CB, Hellkamp AS, Lokhnygina Y, Piccini JP, Breithardt G, Mahaffey KW, Singer DE, Hacke W, Halperin JL, Hankey GJ, Berkowitz SD, Nessel CC, Becker RC, Fox KA, Patel MR; ROCKET AF Steering Committee and Investigators. Circulation. 2017 Mar 7;135(10):1001-1003.

Impact of Heart Transplantation on the Functional Status of US Children With End-Stage Heart Failure. Peng DM, Zhang Y, Rosenthal DN, Palmon M, Chen S, Kaufman BD, Maeda K, Hollander SA, McDonald N, Smoot LB, Bernstein D, Almond CS. Circulation. 2017 Mar 7;135(10):939-950.

Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring. Cao Y, Hjort M, Chen H, Birey F, Leal-Ortiz SA, Han CM, Santiago JG, Paşca SP, Wu JC, Melosh NA. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1866-E1874.

Genome Editing in Cardiovascular Biology. Seeger T, Porteus M, Wu JC. Circ Res. 2017 Mar 3;120(5):778-780.

Clinical and pathological evolution of giant cell arteritis: a prospective study of follow-up temporal artery biopsies in 40 treated patients. Maleszewski JJ, Younge BR, Fritzlen JT, Hunder GG, Goronzy JJ, Warrington KJ, Weyand CM. Mod Pathol. 2017 Mar 3.

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease. Chao MP, Gentles AJ, Chatterjee S, Lan F, Reinisch A, Corces MR, Xavy S, Shen J, Haag D, Chanda S, Sinha R, Morganti RM, Nishimura T, Ameen M, Wu H, Wernig M, Wu JC, Majeti R. Cell Stem Cell. 2017 Mar 2;20(3):329-344.e7.

Functional status of United States children supported with a left ventricular assist device at heart transplantation. Bulic A, Maeda K, Zhang Y, Chen S, McElhinney DB, Dykes JC, Hollander AM, Hollander SA, Murray J, Reinhartz O, Gowan MA, Rosenthal DN, Almond CS. J Heart Lung Transplant. 2017 Mar 2.

The safety and efficacy of full- versus reduced-dose betrixaban in the Acute Medically Ill VTE (Venous Thromboembolism) Prevention With Extended-Duration Betrixaban (APEX) trial. Gibson CM, Halaby R, Korjian S, Daaboul Y, Arbetter DF, Yee MK, Goldhaber SZ, Hull R, Hernandez AF, Lu SP, Bandman O, Leeds JM, Gold A, Harrington RA, Cohen AT; APEX Investigators. Am Heart J. 2017 Mar;185:93-100.

Cardioversion and subsequent quality of life and natural history of atrial fibrillation. Pokorney SD, Kim S, Thomas L, Fonarow GC, Kowey PR, Gersh BJ, Mahaffey KW, Peterson ED, Piccini JP; Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Investigators. Am Heart J. 2017 Mar;185:59-66.

Results of a curtailed randomized controlled trial, evaluating the efficacy and safety of azimilide in patients with implantable cardioverter-defibrillators: The SHIELD-2 trial. Robinson VM, Bharucha DB, Mahaffey KW, Dorian P, Kowey PR; SHIELD-2 Investigators. Am Heart J. 2017 Mar;185:43-51.

Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension. Bonnet S, Provencher S, Guignabert C, Perros F, Boucherat O, Schermuly RT, Hassoun PM, Rabinovitch M, Nicolls MR, Humbert M. Am J Respir Crit Care Med. 2017 Mar 1;195(5):583-595.

A semi-interpenetrating network of polyacrylamide and recombinant basement membrane allows pluripotent cell culture in a soft, ligand-rich microenvironment. Price AJ, Huang EY, Sebastiano V, Dunn AR. Biomaterials. 2017 Mar;121:179-192.

Alternative Approaches for Ablation of Resistant Ventricular Tachycardia. Gianni C, Mohanty S, Trivedi C, Di Biase L, Al-Ahmad A, Natale A, David Burkhardt J. Card Electrophysiol Clin. 2017 Mar;9(1):93-98.

Impact of analysis interval size on the quality of optical frequency domain imaging assessments of stent implantation for lesions of the superficial femoral artery. Miki K, Fujii K, Kawasaki D, Shibuya M, Fukunaga M, Imanaka T, Tamaru H, Sumiyoshi A, Nishimura M, Horimatsu T, Saita T, Kobayashi Y, Honda Y, Fitzgerald PJ, Masuyama T, Ishihara M. Catheter Cardiovasc Interv. 2017 Mar 1;89(4):735-745.

Rationale, design and baseline characteristics of the CANagliflozin cardioVascular Assessment Study-Renal (CANVAS-R): A randomized, placebo-controlled trial. Neal B, Perkovic V, Matthews DR, Mahaffey KW, Fulcher G, Meininger G, Erondu N, Desai M, Shaw W, Vercruysse F, Yee J, Deng H, de Zeeuw D; CANVAS-R Trial Collaborative Group. Diabetes Obes Metab. 2017 Mar;19(3):387-393.

Use of thienopyridine prior to presentation with non-ST-segment elevation acute coronary syndrome and association with safety and efficacy of vorapaxar: insights from the TRACER trial. Harskamp RE, Clare RM, Ambrosio G, Held C, Lokhnygina Y, Moliterno DJ, White HD, Aylward PE, Armstrong PW, Mahaffey KW, Harrington RA, Van de Werf F, Wallentin L, Strony J, Tricoci P. Eur Heart J Acute Cardiovasc Care. 2017 Mar;6(2):155-163.

'Off-the-shelf' immunotherapy with iPSC-derived rejuvenated cytotoxic T lymphocytes. Ando M, Nakauchi H. Exp Hematol. 2017 Mar;47:2-12.

Interleukin-10-mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling. Balaji S, Wang X, King A, Le LD, Bhattacharya SS, Moles CM, Butte MJ, de Jesus Perez VA, Liechty KW, Wight TN, Crombleholme TM, Bollyky PL, Keswani SG. FASEB J. 2017 Mar;31(3):868-881.

Abnormal regional activity and functional connectivity in resting-state brain networks associated with etiology confirmed unilateral pulsatile tinnitus in the early stage of disease. Lv H, Zhao P, Liu Z, Li R, Zhang L, Wang P, Yan F, Liu L, Wang G, Zeng R, Li T, Dong C, Gong S, Wang Z. Hear Res. 2017 Mar;346:55-61.

Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties. Das M, Du Y, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS. J Am Chem Soc. 2017 Mar 1;139(8):3072-3081.

Right-Dominant Unbalanced Atrioventricular Septal Defect: Echocardiography in Surgical Decision Making. Arunamata A, Balasubramanian S, Mainwaring R, Maeda K, Selamet Tierney ES. J Am Soc Echocardiogr. 2017 Mar;30(3):216-226.

Extraction of left ventricular ejection fraction information from various types of clinical reports. Kim Y, Garvin JH, Goldstein MK, Hwang TS, Redd A, Bolton D, Heidenreich PA, Meystre SM. J Biomed Inform. 2017 Mar;67:42-48.

Current status of domino heart transplantation. Shudo Y, Ma M, Boyd JH, Woo YJ. J Card Surg. 2017 Mar;32(3):229-232.

The Role of Cone-Beam CT in Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Systematic Review and Meta-analysis. Pung L, Ahmad M, Mueller K, Rosenberg J, Stave C, Hwang GL, Shah R, Kothary N. J Vasc Interv Radiol. 2017 Mar;28(3):334-341.

Western Vascular Society guidelines for transfer of patients with ruptured abdominal aortic aneurysm. Mell MW, Starnes BW, Kraiss LW, Schneider PA, Pevec WC. J Vasc Surg. 2017 Mar;65(3):603-608.

Disaggregation of Cause-Specific Cardiovascular Disease Mortality Among Hispanic Subgroups. Rodriguez F, Hastings KG, Boothroyd DB, Echeverria S, Lopez L, Cullen M, Harrington RA, Palaniappan LP. JAMA Cardiol. 2017 Mar 1;2(3):240-247.

Trends in Palliative Care Use in Elderly Men and Women With Severe Heart Failure in the United States-Reply. Mandawat A, Heidenreich PA, Bhatt DL. JAMA Cardiol. 2017 Mar 1;2(3):344-345.

Poor medication adherence in clinical trials: consequences and solutions. Breckenridge A, Aronson JK, Blaschke TF, Hartman D, Peck CC, Vrijens B. Nat Rev Drug Discov. 2017 Mar;16(3):149-150.

Regulation of the microenvironment for cardiac tissue engineering. Wanjare M, Huang NF. Regen Med. 2017 Mar;12(2):187-201.