February 2017 Member Publications

Selected Publications

A Comprehensive TALEN-Based Knockout Library for Generating Human Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo NA, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC. Circ Res. 2017 Feb 28.

The Sound of Silence: How Much Noise Should We Make About Postablation Silent Strokes? Zei PC, Vora N. Circulation. 2017 Feb 28;135(9):878-880.

Optimizing the analysis strategy for the CANVAS Program: A prespecified plan for the integrated analyses of the CANVAS and CANVAS-R trials. Neal B, Perkovic V, Mahaffey KW, Fulcher G, Erondu N, Desai M, Shaw W, Law G, Walton MK, Rosenthal N, de Zeeuw D, Matthews DR; CANVAS Program collaborative group. Diabetes Obes Metab. 2017 Feb 28.

Development of [₁₈F]DASA-23 for Imaging Tumor Glycolysis Through Noninvasive Measurement of Pyruvate Kinase M2. Beinat C, Alam IS, James ML, Srinivasan A, Gambhir SS. Mol Imaging Biol. 2017 Feb 24.

Clonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate. Wahlestedt M, Erlandsson E, Kristiansen T, Lu R, Brakebusch C, Weissman IL, Yuan J, Martin-Gonzalez J, Bryder D. Nat Commun. 2017 Feb 22;8:14533.

Crystal structure of the adenosine A_2A receptor bound to an antagonist reveals a potential allosteric pocket. Sun B, Bachhawat P, Chu ML, Wood M, Ceska T, Sands ZA, Mercier J, Lebon F, Kobilka TS, Kobilka BK. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2066-2071. Feb 6.

Impact of stent diameter on vascular response after self-expanding paclitaxel-eluting stent implantation in the superficial femoral artery. Miki K, Fujii K, Shibuya M, Fukunaga M, Imanaka T, Kawai K, Tamaru H, Sumiyoshi A, Nishimura M, Horimatsu T, Saita T, Yoshihara N, Kimura T, Honda Y, Fitzgerald PJ, Masuyama T, Ishihara M. J Cardiol. 2017 Feb 18.

Mammalian Heart Regeneration: The Race to the Finish Line. Doppler SA, Deutsch MA, Serpooshan V, Li G, Dzilic E, Lange R, Krane M, Wu SM. Circ Res. 2017 Feb 17;120(4):630-632.

"Attack of the Clones": Commonalities Between Cancer and Atherosclerosis. DiRenzo D, Owens GK, Leeper NJ. Circ Res. 2017 Feb 17;120(4):624-626.

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions. Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, González Díez M, Perisic Matic L, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Paulsson-Berne G, Hedin U, Maegdefessel L. Circ Res. 2017 Feb 17;120(4):633-644.

Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors. Yang J, Tanaka Y, Seay M, Li Z, Jin J, Garmire LX, Zhu X, Taylor A, Li W, Euskirchen G, Halene S, Kluger Y, Snyder MP, Park IH, Pan X, Weissman SM. Nucleic Acids Res. 2017 Feb 17;45(3):1281-1296.

Fibroblasts become fat to reduce scarring. Chan CK, Longaker MT. Science. 2017 Feb 17;355(6326):693-694.

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC. Sci Transl Med. 2017 Feb 15;9(377).

Extended-Duration Betrixaban Reduces the Risk of Stroke Versus Standard-Dose Enoxaparin Among Hospitalized Medically Ill Patients: An APEX Trial Substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban). Gibson CM, Chi G, Halaby R, Korjian S, Daaboul Y, Jain P, Arbetter D, Goldhaber SZ, Hull R, Hernandez AF, Gold A, Bandman O, Harrington RA, Cohen AT; APEX Investigators. Circulation. 2017 Feb 14;135(7):648-655.

Coronary Artery Development: Progenitor Cells and Differentiation Pathways. Sharma B, Chang A, Red-Horse K. Annu Rev Physiol. 2017 Feb 10;79:1-19.

Two Independent Mapping Techniques Identify Rotational Activity Patterns at Sites of Local Termination During Persistent Atrial Fibrillation. Alhusseini M, Vidmar D, Meckler GL, Kowalewski CA, Shenasa F, Wang PJ, Narayan SM, Rappel WJ. J Cardiovasc Electrophysiol. 2017 Feb 10.

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy. Kawana M, Sarkar SS, Sutton S, Ruppel KM, Spudich JA. Sci Adv. 2017 Feb 10;3(2):e1601959.

Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells. Choi YJ, Lin CP, Risso D, Chen S, Kim TA, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L. Science. 2017 Feb 10;355(6325).

Pneumonia after cardiac surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network. Ailawadi G, Chang HL, O'Gara PT, O'Sullivan K, Woo YJ, DeRose JJ Jr, Parides MK, Thourani VH, Robichaud S, Gillinov AM, Taddei-Peters WC, Miller MA, Perrault LP, Smith RL, Goldsmith L, Horvath KA, Doud K, Baio K, Gelijns AC, Moskowitz AJ, Bagiella E, Alexander JH, Iribarne A. J Thorac Cardiovasc Surg. 2017 Feb 9.

Interspecies organogenesis generates autologous functional islets. Yamaguchi T, Sato H, Kato-Itoh M, Goto T, Hara H, Sanbo M, Mizuno N, Kobayashi T, Yanagida A, Umino A, Ota Y, Hamanaka S, Masaki H, Rashid ST, Hirabayashi M, Nakauchi H. Nature. 2017 Feb 9;542(7640):191-196.

Nanomaterials for In Vivo Imaging. Smith BR, Gambhir SS. Chem Rev. 2017 Feb 8;117(3):901-986.

Superior performance of continuous over pulsatile flow ventricular assist devices in the single ventricle circulation: A computational study. Schmidt T, Rosenthal D, Reinhartz O, Riemer K, He F, Hsia TY, Marsden A, Kung E; Modeling of Congenital Hearts Alliance (MOCHA)+ Investigators. J Biomech. 2017 Feb 8;52:48-54.

Burden of Arrhythmia in Pregnancy. Vaidya VR, Arora S, Patel N, Badheka AO, Patel N, Agnihotri K, Billimoria Z, Turakhia MP, Friedman PA, Madhavan M, Kapa S, Noseworthy PA, Cha YM, Gersh B, Asirvatham SJ, Deshmukh AJ. Circulation. 2017 Feb 7;135(6):619-621.

Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis. Zhang H, Watanabe R, Berry GJ, Vaglio A, Liao YJ, Warrington KJ, Goronzy JJ, Weyand CM. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E970-E979.

The Undiagnosed Diseases Network: Accelerating Discovery about Health and Disease. Ramoni RB, Mulvihill JJ, Adams DR, Allard P, Ashley EA, Bernstein JA, Gahl WA, Hamid R, Loscalzo J, McCray AT, Shashi V, Tifft CJ; Undiagnosed Diseases Network., Wise AL. Am J Hum Genet. 2017 Feb 2;100(2):185-192.

The Pursuit of Engineering the Ideal Heart Valve Replacement or Repair: A Special Issue of the Annals of Biomedical Engineering. Dasi LP, Grande-Allen J, Kunzelman K, Kuhl E. Ann Biomed Eng. 2017 Feb;45(2):307-309.

Laser-Assisted Removal of Embedded Vena Cava Filters: A 5-Year First-in-Human Study. Kuo WT, Odegaard JI, Rosenberg JK, Hofmann LV. Chest. 2017 Feb;151(2):417-424.

Sex Differences in the Performance of Cardiac Computed Tomography Compared With Functional Testing in Evaluating Stable Chest Pain: Subanalysis of the Multicenter, Randomized CRESCENT Trial (Calcium Imaging and Selective CT Angiography in Comparison to Functional Testing for Suspected Coronary Artery Disease). Lubbers M, Coenen A, Bruning T, Galema T, Akkerhuis J, Krenning B, Musters P, Ouhlous M, Liem A, Niezen A, Dedic A, van Domburg R, Hunink M, Nieman K. Circ Cardiovasc Imaging. 2017 Feb;10(2).

Acute Right Ventricular Failure After Successful Opening of Chronic Total Occlusion in Right Coronary Artery Caused by a Large Intramural Hematoma. Kawana M, Lee AM, Liang DH, Yeung AC. Circ Cardiovasc Interv. 2017 Feb;10(2).

Healthcare Utilization and Expenditures Associated With Appropriate and Inappropriate Implantable Defibrillator Shocks.Turakhia MP, Zweibel S, Swain AL, Mollenkopf SA, Reynolds MR. Circ Cardiovasc Qual Outcomes. 2017 Feb;10(2).

Biomarkers and Coronary Lesions Predict Outcomes after Revascularization in Non-ST-Elevation Acute Coronary Syndrome. Lindholm D, James SK, Bertilsson M, Becker RC, Cannon CP, Giannitsis E, Harrington RA, Himmelmann A, Kontny F, Siegbahn A, Steg PG, Storey RF, Velders MA, Weaver WD, Wallentin L; PLATO Investigators.Clin Chem. 2017 Feb;63(2):573-584.

Peptidomimetic therapeutics: scientific approaches and opportunities. Qvit N, Rubin SJ, Urban TJ, Mochly-Rosen D, Gross ER. Drug Discov Today. 2017 Feb;22(2):454-462.

Loss of smooth muscle cell hypoxia inducible factor-1α underlies increased vascular contractility in pulmonary hypertension. Barnes EA, Chen CH, Sedan O, Cornfield DN. FASEB J. 2017 Feb;31(2):650-662.

Electroanatomic Properties of the Myocardium Predict Response to CD34+ Cell Therapy in Patients With Ischemic and Nonischemic Heart Failure. Zemljic G, Poglajen G, Sever M, Cukjati M, Frljak S, Androcec V, Cernelc P, Haddad F, Vrtovec B. J Card Fail. 2017 Feb;23(2):153-160.

Use of the triglyceride/high-density lipoprotein cholesterol ratio to identify cardiometabolic risk: impact of obesity? Salazar MR, Carbajal HA, Espeche WG, Aizpurúa M, Marillet AG, Leiva Sisnieguez CE, Leiva Sisnieguez BC, Stavile RN, March CE, Reaven GM. J Investig Med. 2017 Feb;65(2):323-327.

TRANSFORM (Multicenter Experience With Rapid Deployment Edwards INTUITY Valve System for Aortic Valve Replacement) US clinical trial: Performance of a rapid deployment aortic valve. Barnhart GR, Accola KD, Grossi EA, Woo YJ, Mumtaz MA, Sabik JF, Slachman FN, Patel HJ, Borger MA, Garrett HE Jr, Rodriguez E, McCarthy PM, Ryan WH, Duhay FG, Mack MJ, Chitwood WR Jr; TRANSFORM Trial Investigators. J Thorac Cardiovasc Surg. 2017 Feb;153(2):241-251.e2.

The Role of Dual-Phase Cone-Beam CT in Predicting Short-Term Response after Transarterial Chemoembolization for Hepatocellular Carcinoma. Müller K, Datta S, Gehrisch S, Ahmad M, Mohammed MA, Rosenberg J, Hwang GL, Louie JD, Sze DY, Kothary N. J Vasc Interv Radiol. 2017 Feb;28(2):238-245.

Yttrium-90 Radioembolization with Resin Microspheres without Routine Embolization of the Gastroduodenal Artery. Ward TJ, Louie JD, Sze DY. J Vasc Interv Radiol. 2017 Feb;28(2):246-253.

Cost-Effectiveness of Left Ventricular Assist Devices in Ambulatory Patients With Advanced Heart Failure. Baras Shreibati J, Goldhaber-Fiebert JD, Banerjee D, Owens DK, Hlatky MA. JACC Heart Fail. 2017 Feb;5(2):110-119.

Factors Associated With and Prognostic Implications of Cardiac Troponin Elevation in Decompensated Heart Failure With Preserved Ejection Fraction: Findings From the American Heart Association Get With The Guidelines-Heart Failure Program. Pandey A, Golwala H, Sheng S, DeVore AD, Hernandez AF, Bhatt DL, Heidenreich PA, Yancy CW, de Lemos JA, Fonarow GC. JAMA Cardiol. 2017 Feb 1;2(2):136-145.

Evaluation of Ischemic and Bleeding Risks Associated With 2 Parenteral Antiplatelet Strategies Comparing Cangrelor With Glycoprotein IIb/IIIa Inhibitors: An Exploratory Analysis From the CHAMPION Trials. Vaduganathan M, Harrington RA, Stone GW, Deliargyris EN, Steg PG, Gibson CM, Hamm CW, Price MJ, Menozzi A, Prats J, Elkin S, Mahaffey KW, White HD, Bhatt DL. JAMA Cardiol. 2017 Feb 1;2(2):127-135.

Prediction of 30-Day All-Cause Readmissions in Patients Hospitalized for Heart Failure: Comparison of Machine Learning and Other Statistical Approaches. Frizzell JD, Liang L, Schulte PJ, Yancy CW, Heidenreich PA, Hernandez AF, Bhatt DL, Fonarow GC, Laskey WK. JAMA Cardiol. 2017 Feb 1;2(2):204-209.

Reference Standards for Cardiorespiratory Fitness Measured With Cardiopulmonary Exercise Testing Using Cycle Ergometry: Data From the Fitness Registry and the Importance of Exercise National Database (FRIEND) Registry. Kaminsky LA, Imboden MT, Arena R, Myers J. Mayo Clin Proc. 2017 Feb;92(2):228-233.

Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin. Stanton BZ, Hodges C, Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K, Crabtree GR. Nat Genet. 2017 Feb;49(2):282-288.

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Furman D, Chang J, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Déchanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. Nat Med. 2017 Feb;23(2):174-184.

Perioperative Retinal Artery Occlusion: Risk Factors in Cardiac Surgery from the United States National Inpatient Sample 1998-2013. Calway T, Rubin DS, Moss HE, Joslin CE, Beckmann K, Roth S. Ophthalmology. 2017 Feb;124(2):189-196.

Rehospitalization after pediatric heart transplantation: Incidence, indications, and outcomes. Hollander SA, McElhinney DB, Almond CS, McDonald N, Chen S, Kaufman BD, Bernstein D, Rosenthal DN. Pediatr Transplant. 2017 Feb;21(1).

Epigenomics of human CD8 T cell differentiation and aging. Moskowitz DM, Zhang DW, Hu B, Le Saux S, Yanes RE, Ye Z, Buenrostro JD, Weyand CM, Greenleaf WJ, Goronzy JJ. Sci Immunol. 2017 Feb;2(8).