Daniel Bernstein
Academic Appointments
Appointment
Organization
Professor
Member
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Honors & Awards
Title
Organization
Date(s)
Alfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics
Stanford University
April 2004-present
Administrative Appointments
Title
Organization
Start Year
End Year
Co-Director, Children's Heart Center
Packard Children's Hospital at Stanford
2001
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Research Interests
We are interested in the role of the sympathetic nervous system and its cellular components (adrenergic receptors, G proteins) in regulating cardiac development and function. We are also interested in developing tools for examination of cardiovascular physiologic parameters in transgenic and targeted gene disruption mouse models of cardiovascular disease. Specific projects underway in our lab include:
1. Evaluation of the role of beta1 and beta2 adrenergic receptor subtypes in regulating cardiac structure and function by producing mice with targeted gene disruption of these receptors.
2. Evaluation of the role of crosstalk between beta receptors and other signaling pathways (MAPK,Akt,PKC) in regulating cardiac structure and function.
3. Role of beta receptors in regulation of intracellular and intramitochondrial calcium.
4. Role of beta receptors in adriamycin cardiotoxicity.
5. Exercise physiology in the mouse
6. Gene microarray analysis of cardiomyopathy models.
We also are interested in clinical cardiac transplantation in children, specifically:
1. The application of gene microarray methods of cardiac allograft rejection in pediatric patients.
2. Assessment of new techniques of immunosuppression in children.
3. Long-term complications in pediatric heart transplant patients.
1. Evaluation of the role of beta1 and beta2 adrenergic receptor subtypes in regulating cardiac structure and function by producing mice with targeted gene disruption of these receptors.
2. Evaluation of the role of crosstalk between beta receptors and other signaling pathways (MAPK,Akt,PKC) in regulating cardiac structure and function.
3. Role of beta receptors in regulation of intracellular and intramitochondrial calcium.
4. Role of beta receptors in adriamycin cardiotoxicity.
5. Exercise physiology in the mouse
6. Gene microarray analysis of cardiomyopathy models.
We also are interested in clinical cardiac transplantation in children, specifically:
1. The application of gene microarray methods of cardiac allograft rejection in pediatric patients.
2. Assessment of new techniques of immunosuppression in children.
3. Long-term complications in pediatric heart transplant patients.
Publications
- Norman JJ, Mukandan V, Bernstein D, Pruitt BL "Microsystems for Biomechanical Measurements." Pediatr Res 2008; More »
- Bernstein D, Williams GE, Eisen H, Mital S, Wohlgemuth JG, Klingler TM, Fang KC, Deng MC, Kobashigawa J "Gene expression profiling distinguishes a molecular signature for grade 1B mild acute cellular rejection in cardiac allograft recipients." J Heart Lung Transplant 2007; 26: 12: 1270-80 More »
- Fajardo G, Zhao M, Powers J, Bernstein D "Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy." J Mol Cell Cardiol 2006; More »
- Ross M, Kouretas P, Gamberg P, Miller J, Burge M, Reitz B, Robbins R, Chin C, Bernstein D "Ten- and 20-year Survivors of Pediatric Orthotopic Heart Transplantation." J Heart Lung Transplant 2006; 25: 3: 261-70 More »
- Alkhaldi A, Chin C, Bernstein D "Pediatric cardiac transplantation." Semin Pediatr Surg 2006; 15: 3: 188-198 More »
70 publications: view full list