Clinical Focus

• Anatomic Pathology,
• Diagnostic neuropathology

Research Interest

We study cellular and molecular mechanisms of immune-mediated injury in central nervous system (CNS) tissues that are altered in multiple sclerosis (MS). Tissues of patients and of animals with experimental allergic encephalomyelitis are analyzed using histology and immunohistochemistry. We currently are studying the cross-recognition of neurons by antibodies against myelin proteolipid protein epitopes. Similar cross-recognition may link anti-myelin immunity with neurodegeneration in MS.

Research Interest

My primary interest is to understand the flow of information from the genome to the phenotype of an organism. This interest includes predicting the structure and function of genes and proteins from their primary sequence, predicting function from structure and finally simulating protein folding and ligand docking. These goals are the same as the goals of molecular biology, however, we use primarily computational approaches.

Clinical Focus

• Cardiovascular Disease

Research Interest

The ultimate goal of my laboratory is to define the molecular mechanisms underlying cardiovascular development and disease and translate the bench findings to clinical applications. One objective is to understand how the major types of cardiac cells (endocardial, myocardial, epicardial and neural crest cells) interact with each other to generate heart tissues. We are interested in chromatin regulation, transcriptional and signaling events that coordinate their interactions and assembly into heart tissues. We also study vascular regeneration and repair after injury with emphasis on vascular stem cell biology. The goal is to understand the developmental mechanisms that control tissue formation and repair in order to recapitulate the developmental processes for therapeutic or regenerative purposes. Another objective is to apply lessons learned from developmental studies to investigating the mechanisms underlying adult cardiovascular diseases. We are interested in determining the mechanistic links between cardiac development and adult cardiomyopathy. Furthermore, as part of the effort to understand tissue repair mechanisms following injury, we are investigating the biology of adult stem cells in various tissues that include hair follicles and blood vessels under different pathophysiological conditions. Our goal is to integrate developmental biology, adult pathophysiology, and regenerative medicine toward the understanding and treatment of human diseases.

Clinical Focus

• Emergency Medicine

Research Interest

Current active research -> Computer-based Decision Support for therapeutic management of patients with multimorbidy, (Musen Lab) -> Effects of Mindfulness Based Stress Reduction (MBSR) on non-atherosclerotic angina in women, (clinical trial with Dr. Jennifer Tremmel) Areas of active interest: -> Novel uses for information technology in emergency medicine. -> Effects of cognitive-based therapy and MBSR on perception of pain. -> Health and education

Research Interest

Evaluation of novel PET detectors based on semiconductor photodetectors, Design and development of hardware for MR compatible PET system, Image correction methods for PET images.

Research Interest

The Wu lab studies the biological mechanisms of adult stem cells, embryonic stem cells, and induced pluripotent stem cells.

Research Interest

My research focuses on the molecular mechanisms driving cardiovascular development, disease, and regeneration. I am also interested in utilizing induced pluripotent stem cells for the in-vitro modeling of cardiovascular disorders.

Research Interest

My research and educational activities focus on evidence-based medicine, patient-centered concerns, health care quality, and patient safety. I enjoy forming and participating in multi-disciplinary teams to identify, highlight and formulate solutions to issues of suboptimal performance of the health care system, both in the US and abroad.

Clinical Focus

• Pulmonary Critical Care,
• Pulmonary Disease

Clinical Focus

• Advanced modes of noninvasive ventilation,
• CPAP adherence,
• Central Sleep Apnea,
• Sleep Medicine

Research Interest

Positive Airway Pressure devices for central sleep apnea

Clinical Focus

• Cancer > Cutaneous (Dermatologic) Oncology,
• Cancer- cutaneous oncology,
• Dermatopathology,
• Melanocytic neoplasia